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DNP (2,4-Dinitrophenol), an industrial chemical with various applications, has gained steady popularity as a fat loss tool. Boasting an astounding 50% increase in metabolic rate, it is able to contribute to reported fat losses of 10-12 pounds in 8 days of use. Classified as an “uncoupler of oxidative phosphorylation” medically, it is quite dangerous as there is no negative feedback system that may deal with overdoses. Specifically, there is no upper limit to the increase in body temperature that may be obtained with its use.
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IUPAC name: 2,4-Dinitrophenol
Molecular formula: C6H4N2O5.
Molar Mass: 184.106
Density: 1.683 g/cm³
Melting Point:108 °C, 381 K, 226 °F
Boiling Point: 113 °C, 386 K, 235 °F
What is DNP?
For purposes of this article we will stick to the physiological application of DNP. If I had to describe DNP in one word…poison. DNP prevents normal chemical reactions at the cellular level. It impedes the normal function of cellular metabolism.
How does DNP work?
DNP makes changes in our metabolism. Metabolism is the set of chemical reactions in our bodies that keep us alive. Our bodies metabolize nutrients to provide us with energy. Oxidation involves the transfer of electrons between atoms (or molecules) and releases energy. The formal name for this process is oxidative phosphorylation.
How is DNP Dangerous?
- DNP can kill you. We discussed how DNP converts the energy from food into heat energy, which increases body temperature. Unfortunately there is no limit to how high your body temperature can get while on DNP, so it can literally “cook” you.
- DNP can cause fever, stroke, nephritis, tachycardia, respiration problems, coma, and peripheral neuritis.
What are the benefits of DNP?
- Fat loss
- Anabolic rebound – After a DNP cycle the body is in a highly anabolic state.
- T3 reduction – If you happen to be running DNP right after an AAS
- cycle, the DNP can reduce the excessive T3 production that causes much of the
- catabolic type muscle loss post cycle.
Note: DNP can lower T3 to below optimal levels, so in some cases it may be necessary to start taking small doses of T3.
How should I take DNP?
I have a conservative stance on when to use DNP, how much to use, and how long to use it.Some people argue that DNP should be used on cycle so as to protect muscle. My contention is that DNP makes you feel like crap, and it can detract from lifting at your best while on cycle. If I am on cycle I want to be lifting hard and I do not want to worry about energy levels or heat stroke.
Low Dose Long Cycle
Start with a dose of 200mg per day [100 mg every morning / 100 mg
every evening]. Run it for two or three weeks.
Day 1 – 14: 200 mg ED
Day 15 – 21: 200 mg ED
What are common sides to DNP?
- Discomfort and sweating
- Yellow bodily fluids
- Muscle Soreness
- Allergic Reactions
- Carbohydrate Cravings
- Vomiting (a good sign that you should stop)
What food and supplements should I take while on a DNP cycle?
You may lose your senses of taste and smell so this is a good time to teach yourself how to eat without using condiments and all the other crap you dont need.Water – One or two gallons a day. Dehydration is the leading cause of DNP problems, including death.
- Fruit – Glycogen will be depleated. Fructose is good.
- Protein – Diet should be heavy on protein.
- Fiber – DNP can be rough so you may want to regulate (pun intended).
- Complex Carbs – Carbs will make you hot. You should try to time your carb intake so that you are not eating carbs before workouts or before sleep.
- Multi vitamin – You are likely to be on a rescticted diet and you will need to supplement.
- Antioxidants – To stop the free radicals
DNP 7 days cycles :
the first 3 days – 200 mg per day;
the next 4 days – 400 mg per day (which means you should take 400 mg for 4 days).
2,4-Dinitrophenol, more commonly known as DNP, is a solid yellow crystaline that has a sweet, musty odor. It is a manufactured chemical that does not occur naturally in the environment.
2,4-Dinitrophenol (DNP) has many uses, 2,4-dinitrophenol is most notorious as a dangerous yet effective weight loss agent and fat burner in the hardcore underground bodybuilding supplement industry.
2,4-Dinitrophenol DNP In The World Of Bodybuilding
Originally used as an ignitor for TNT as well as a pesticide, researchers at Stanford University discovered that DNP causes weight loss in 1933. The late pioneer bodybuilding Dan Duchaine wrote about DNP for fat reducing weight loss and DNP has been used in the hardcore bodybuilding underground for fat and weight loss for decades.
Weight Loss with DNP – Scientifically Speaking
DNP accomplishes the astounding boost in metabolic rate via inhibition of the F0F1 ATP synthase molecule, located in the inner wall of each mitochondrion. While the electron transport chain still functions to pump hydrogen ions into the inter-membrane space, the coupling of the proton gradient to ATP production is rendered impossible by DNP. As a result, ATP production is dramatically reduced, and the energy is instead thrown off as heat.
Risks of using 2,4-Dinitrophenol DNP for Weight Loss
Hearing all of these wonderful things probably has you wondering what the side effects and risks are. They are quite formidable and contribute to making DNP one of the most intolerable (though effective) drugs used in bodybuilding.
Safe and Effective DNP Dosage…
…at least as safe as it gets when using DNP for weight loss. Dosing is highly individualized and most generalizations tend to collapse quite quickly. As a result, none will be attempted. Start on the low end of the scale and see how you react.
Timetable of Effects and Symptoms of a DNP Cycle
DNP CYCLE Day 1 -None; possibly elevated carbohydrate cravings and/or temperature elevation.
DNP CYCLE Day 2 – T4-T3 conversion has begun to decrease; lethargy possible. Temperature should be elevated, and radiation of heat is noticeable.
This product is designed for research and laboratory purposes only. The product is not a pharmaceutical drug or dietary supplement.